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Peptide record

TPDB34656

Neurotoxin Toxicity standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB34656
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 82-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKVAIVFLSLLVLAFASESIEENREEFPVEESARCGDINAACKEDCDCCGYTTACDCYWSKSCKCREAAIVIYTAPKKKLTC
Physicochemical Analysis
C392H623N101O124S11
QH
AC
9087.52
4.67
10
13
33
-3
19.17
0.074
77.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
10595
116.59
25
Residue Composition
number
10
A
3
R
2
N
4
D
10
C
9
E
0
Q
2
G
0
H
5
I
5
L
7
K
1
M
3
F
2
P
6
S
4
T
1
W
3
Y
5
V
Amino Acid Distribution
A: 10 R: 3 N: 2 D: 4 C: 10 E: 9 Q: 0 G: 2 H: 0 I: 5 L: 5 K: 7 M: 1 F: 3 P: 2 S: 6 T: 4 W: 1 Y: 3 V: 5
Chemical Descriptors
82
C392H623N101O124S11
9087.52
4.67
-3
19.17
0.074
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation (PubMed:12770132). The toxin also inhibits glutamate uptake from rat brain synaptosomes (PubMed:14757211). It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) (By similarity). In addition, the toxin shows antinociceptive effect in all rat pain models tested (inflammatory, neuropathic and nociceptive) (PubMed:27077886). The antinociceptive effect is partially blocked when selective antagonists of both mu- and delta-opioid receptors are administered, revealing that the antinociceptive effect of the toxin involves both opioid and cannabinoid endogenous systems (PubMed:27077886). In vivo, it is highly toxic to house fly (Musca domestica), toxic to cockroach, but has no effect when intracerebroventricularly injected into mice (PubMed:12770132, PubMed:7778132). {ECO:0000250|UniProtKB:P59367, ECO:0000269|PubMed:12770132, ECO:0000269|PubMed:14757211, ECO:0000269|PubMed:27077886, ECO:0000269|PubMed:7778132}.

Target

voltage-gated sodium channel (Nav) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation (PubMed:12770132). The toxin also inhibits glutamate uptake from rat brain synaptosomes (PubMed:14757211).
Delta-ctenitoxin-Pn1a (Delta-CNTX-Pn1a) (Insecticidal neurotoxin Tx4(6-1)) (PnTx4(6-1))
spider
Neurotoxin 03 (Tx2) family, 05 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7778132}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 05 subfamily
Delta-ctenitoxin-Pn1a (Delta-CNTX-Pn1a) (Insecticidal neurotoxin Tx4(6-1)) (PnTx4(6-1))
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7778132}.
spider