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Peptide record

TPDB34654

Neurotoxin Toxicity standard
88 amino acids
Basic Information
3D PDB MODEL
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TPDB34654
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 88-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKVAILILSILVLAVASETIEEYRDDFAVEELERATCAGQDKPCKETCDCCGERGECVCALSYEGKYRCICRQGNFLIAWHKLASCKK
Physicochemical Analysis
C424H686N116O130S11
CE
9841.47
5.21
13
14
35
-2
23.00
0.010
88.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
10595
107.66
23
Residue Composition
number
9
A
5
R
1
N
4
D
10
C
10
E
2
Q
5
G
1
H
6
I
8
L
7
K
1
M
2
F
1
P
4
S
3
T
1
W
3
Y
5
V
Amino Acid Distribution
A: 9 R: 5 N: 1 D: 4 C: 10 E: 10 Q: 2 G: 5 H: 1 I: 6 L: 8 K: 7 M: 1 F: 2 P: 1 S: 4 T: 3 W: 1 Y: 3 V: 5
Chemical Descriptors
88
C424H686N116O130S11
9841.47
5.21
-2
23.00
0.010
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated sodium channels (Nav) (By similarity). Causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 1.62 mg/mouse. Insecticidal to the larval and adult forms of the house fly. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits voltage-gated sodium channels (Nav) (By similarity). Causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 1.62 mg/mouse.
U2-ctenitoxin-Pn1a (U2-CNTX-Pn1a) (Neurotoxin Tx2-1)
spider
Neurotoxin 03 (Tx2) family, 04 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 04 subfamily
U2-ctenitoxin-Pn1a (U2-CNTX-Pn1a) (Neurotoxin Tx2-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
spider