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Peptide record

TPDB34653

Neurotoxin Toxicity standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB34653
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 82-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKVAILFLSILVLAVASESIEESRDDFAVEELGRATCAGQDQTCKVTCDCCGERGECVCGGPCICRQGNFLIAWYKLASCKK
Physicochemical Analysis
C378H614N104O118S11
H
C
8856.32
4.79
9
11
32
-2
15.78
0.260
88.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7615
85.98
23
Residue Composition
number
8
A
4
R
1
N
4
D
10
C
7
E
3
Q
7
G
0
H
5
I
7
L
5
K
1
M
3
F
1
P
5
S
3
T
1
W
1
Y
6
V
Amino Acid Distribution
A: 8 R: 4 N: 1 D: 4 C: 10 E: 7 Q: 3 G: 7 H: 0 I: 5 L: 7 K: 5 M: 1 F: 3 P: 1 S: 5 T: 3 W: 1 Y: 1 V: 6
Chemical Descriptors
82
C378H614N104O118S11
8856.32
4.79
-2
15.78
0.260
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversible inhibitor of voltage-gated sodium channels (Nav). Delays the fast inactivation kinetics of neuronal-type sodium channels. In vivo, it induces rat penile erection (PubMed:15246765). This effect may be due to the neuronal nitric oxide synthase (NOS1), since one of its selective inhibitor completely abolishes all the toxic effects of the toxin (PubMed:15246765). This toxin also causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 0.24 mg/mouse (PubMed:1397265, PubMed:15246765, PubMed:16278100). It is also insecticidal to the larval and adult forms of the house fly (PubMed:1397265). {ECO:0000269|PubMed:1397265, ECO:0000269|PubMed:15246765, ECO:0000269|PubMed:16278100, ECO:0000269|PubMed:19231838}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Reversible inhibitor of voltage-gated sodium channels (Nav). Delays the fast inactivation kinetics of neuronal-type sodium channels.
Delta-ctenitoxin-Pn2c (Delta-CNTX-Pn2c) (Neurotoxin Pn2-5A) (Neurotoxin Tx2-5) (PnTx2-5)
spider
Neurotoxin 03 (Tx2) family, 06 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1397265, ECO:0000305|PubMed:16278100, ECO:0000305|PubMed:19231838}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 06 subfamily
Delta-ctenitoxin-Pn2c (Delta-CNTX-Pn2c) (Neurotoxin Pn2-5A) (Neurotoxin Tx2-5) (PnTx2-5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1397265, ECO:0000305|PubMed:16278100, ECO:0000305|PubMed:19231838}.
spider