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Peptide record

TPDB34629

Neurotoxin Toxicity standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB34629
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 82-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKTSVVFVIAGLALLSVACYASELKEQSSINEVLSTIFHFEQPEERDCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVFGK
Physicochemical Analysis
C414H655N111O118S9
CLKSV
9363.97
7.92
13
9
32
+2
16.16
-0.017
81.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
94.56
24
Residue Composition
number
4
A
4
R
3
N
3
D
7
C
6
E
2
Q
3
G
2
H
4
I
7
L
7
K
2
M
5
F
3
P
7
S
3
T
1
W
2
Y
7
V
Amino Acid Distribution
A: 4 R: 4 N: 3 D: 3 C: 7 E: 6 Q: 2 G: 3 H: 2 I: 4 L: 7 K: 7 M: 2 F: 5 P: 3 S: 7 T: 3 W: 1 Y: 2 V: 7
Chemical Descriptors
82
C414H655N111O118S9
9363.97
7.92
+2
16.16
-0.017
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent voltage-gated sodium channel blocker (By similarity). Potently inhibits the voltage-gated sodium channels Nav1.7/SCN9A (IC(50)=0.58-10 nM) (By similarity). Shows a moderate activity on Nav1.1/SCN1A (IC(50)=6 nM), Nav1.2/SCN2A (IC(50)=5-128 nM), Nav1.3/SCN3A (IC(50)=20.3-170 nM), and Nav1.6/SCN8A (IC(50)=17-20.1 nM) (By similarity) (PubMed:29703751). Shows an unclear inhibition of Nav1.4/SCN4A (IC(50)=200 nM to >10 uM), Nav1.5/SCN5A (IC(50)=140 nM to >10 uM) and Nav1.8/SCN10A (IC(50)=68-12200 nM) (By similarity) (PubMed:29703751). Weakly blocks the low voltage-gated calcium channels Cav3.1/CACNA1G (30% inhibition of the peak current by 9.8 nM of the toxin) (PubMed:21740921). It shows moderate affinity for lipid bilayers (PubMed:29703751). {ECO:0000250|UniProtKB:P0DL72, ECO:0000250|UniProtKB:P0DL73, ECO:0000269|PubMed:21740921, ECO:0000269|PubMed:29703751}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Potent voltage-gated sodium channel blocker (By similarity). Potently inhibits the voltage-gated sodium channels Nav1.7/SCN9A (IC(50)=0.58-10 nM) (By similarity).
Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) (Beta/omega-TRTX-Gr2a) (GpTx-1) (GpTx-I)
spider
Neurotoxin 10 (Hwtx-1) family, 08 (Gtx1-15) subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21740921}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 08 (Gtx1-15) subfamily
Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) (Beta/omega-TRTX-Gr2a) (GpTx-1) (GpTx-I)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21740921}.
spider