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Peptide record

TPDB34626

Neurotoxin Toxicity standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB34626
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 63-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKTSVFVLVLGLVLLFAVSFATEMEESARECGKFMWKCKNSNDCCKDLVCSSRWKWCVLASPF
Physicochemical Analysis
C322H502N80O87S9
QHIY
LSV
7174.55
8.02
8
6
29
+2
3.16
0.403
81.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
235.21
17
Residue Composition
number
4
A
2
R
2
N
2
D
6
C
4
E
0
Q
2
G
0
H
0
I
7
L
6
K
3
M
5
F
1
P
7
S
2
T
3
W
0
Y
7
V
Amino Acid Distribution
A: 4 R: 2 N: 2 D: 2 C: 6 E: 4 Q: 0 G: 2 H: 0 I: 0 L: 7 K: 6 M: 3 F: 5 P: 1 S: 7 T: 2 W: 3 Y: 0 V: 7
Chemical Descriptors
63
C322H502N80O87S9
7174.55
8.02
+2
3.16
0.403
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits sodium channels Nav1.7/SCN9A and potassium channels Kv11.1/KCNH2. Also binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) with very slow apparent binding kinetics and affects channel gating. Reaches its target by dynamically partitioning into anionic or zwitterionic headgroup lipid membranes. May bind to the open state of KvAP. {ECO:0000269|PubMed:15241419, ECO:0000269|PubMed:15287735, ECO:0000269|PubMed:17002285, ECO:0000269|PubMed:19955179}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits sodium channels Nav1.7/SCN9A and potassium channels Kv11.1/KCNH2. Also binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) with very slow apparent binding kinetics and affects channel gating.
Kappa-theraphotoxin-Gr3a (Kappa-TRTX-Gr3a) (Voltage sensor toxin 1) (VsTx1)
spider
Neurotoxin 10 (Hwtx-1) family, 63 (VsTx1) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 63 (VsTx1) subfamily
Kappa-theraphotoxin-Gr3a (Kappa-TRTX-Gr3a) (Voltage sensor toxin 1) (VsTx1)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider