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Peptide record

TPDB34619

Neurotoxin Toxicity standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB34619
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 63-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKTSILFVIFGLALLFALSVAIEMEEEETDRGCGTMWSPCSTEKPCCDNFSCQPAIKWCIWSP
Physicochemical Analysis
C315H482N74O92S9
HY
CES
7066.27
4.16
4
8
26
-4
5.44
0.316
77.46
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
238.81
18
Residue Composition
number
4
A
1
R
1
N
2
D
6
C
6
E
1
Q
3
G
0
H
5
I
5
L
3
K
3
M
4
F
4
P
6
S
4
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 2 C: 6 E: 6 Q: 1 G: 3 H: 0 I: 5 L: 5 K: 3 M: 3 F: 4 P: 4 S: 6 T: 4 W: 3 Y: 0 V: 2
Chemical Descriptors
63
C315H482N74O92S9
7066.27
4.16
-4
5.44
0.316
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits preferentially tetrodotoxin-insensitive sodium currents (Nav) on rat cardiac myocytes (IC(50) is 0.26 uM) and has weaker inhibition activity toward tetrodotoxin-sensitive sodium currents on rat dorsal root ganglion (DRG) sensory neurons (IC(50) is 0.83 uM) and on cockroach dorsal unpaired median (DUM) neurons (IC(50) is 1.19 uM). Has no significant effect on potassium currents on DRG neurons. {ECO:0000269|PubMed:18840410}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits preferentially tetrodotoxin-insensitive sodium currents (Nav) on rat cardiac myocytes (IC(50) is 0.26 uM) and has weaker inhibition activity toward tetrodotoxin-sensitive sodium currents on rat dorsal root ganglion (DRG) sensory neurons (IC(50) is 0.83 uM) and on cockroach dorsal unpaired median (DUM) neurons (IC(50) is 1.19 uM). Has no significant effect on potassium currents on DRG neurons..
U7-theraphotoxin-Cg1a (U7-TRTX-Cg1a) (Jingzhaotoxin-2) (JZTX-2) (Peptide F2-32.19)
spider
Neurotoxin 10 (Hwtx-1) family, 36 (Jztx-2) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 36 (Jztx-2) subfamily
U7-theraphotoxin-Cg1a (U7-TRTX-Cg1a) (Jingzhaotoxin-2) (JZTX-2) (Peptide F2-32.19)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider