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Peptide record

TPDB34615

Neurotoxin Toxicity standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB34615
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 71-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKTAIFTVVLALAVFAVLCLVVSTHAERHSKTDMEDSPMIQERKGLPPGKPCYGATQKIPCCGVCSHNNCT
Physicochemical Analysis
C331H540N92O97S9
W
V
7649.03
8.02
10
5
27
+2
14.03
0.156
80.99
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
24.38
21
Residue Composition
number
6
A
2
R
2
N
2
D
6
C
3
E
2
Q
4
G
3
H
3
I
5
L
5
K
3
M
2
F
5
P
4
S
6
T
0
W
1
Y
7
V
Amino Acid Distribution
A: 6 R: 2 N: 2 D: 2 C: 6 E: 3 Q: 2 G: 4 H: 3 I: 3 L: 5 K: 5 M: 3 F: 2 P: 5 S: 4 T: 6 W: 0 Y: 1 V: 7
Chemical Descriptors
71
C331H540N92O97S9
7649.03
8.02
+2
14.03
0.156
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells. Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells. Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches (By similarity)..
Hainantoxin-X-2 (HNTX-X-2)
spider
Neurotoxin 36 family, 02 subfamily
Evidence at transcript level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at transcript level
Neurotoxin 36 family, 02 subfamily
Hainantoxin-X-2 (HNTX-X-2)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider