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Peptide record

TPDB34610

Neurotoxin Toxicity standard
105 amino acids
Basic Information
3D PDB MODEL
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TPDB34610
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 105-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKTLVIACVALVLVVVHGEVIEEVNEKQLQESVEEKYSLLQRLEKLDEAITAEENRNSRVRRCGSKRAWCKEKKDCCCGYNCVYAWYNQQSSCERKWKYLFTGEC
Physicochemical Analysis
C533H853N151O162S10
P
E
12289.15
7.44
18
16
39
+1
33.52
-0.481
80.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
24450
198.96
33
Residue Composition
number
6
A
7
R
5
N
2
D
9
C
14
E
5
Q
4
G
1
H
3
I
9
L
10
K
1
M
1
F
0
P
6
S
3
T
3
W
5
Y
11
V
Amino Acid Distribution
A: 6 R: 7 N: 5 D: 2 C: 9 E: 14 Q: 5 G: 4 H: 1 I: 3 L: 9 K: 10 M: 1 F: 1 P: 0 S: 6 T: 3 W: 3 Y: 5 V: 11
Chemical Descriptors
105
C533H853N151O162S10
12289.15
7.44
+1
33.52
-0.481
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selectively slows channel inactivation of mammalian Nav1.1/SCN1A, Nav1.3/SCN3A, and Nav1.6/SCN8A and shows higher affinity for insect Nav1/para channels (site 3). Induces tonic repetitive firing of nerve impulses in insect neurons accompanied by plateau potentials. {ECO:0000269|PubMed:12860384, ECO:0000269|PubMed:19592486}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Selectively slows channel inactivation of mammalian Nav1.1/SCN1A, Nav1.3/SCN3A, and Nav1.6/SCN8A and shows higher affinity for insect Nav1/para channels (site 3). Induces tonic repetitive firing of nerve impulses in insect neurons accompanied by plateau potentials..
Delta-hexatoxin-Mg1a (Delta-HXTX-Mg1a) (Neurotoxin magi-4)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
Additional Detail Fields 7 fields
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Mg1a (Delta-HXTX-Mg1a) (Neurotoxin magi-4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
spider