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Peptide record

TPDB34601

Neurotoxin Toxicity standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB34601
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 86-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKSIVFVALFGLALLAVVCSASEDAHKELLKEVVRAMVVDKTDAVQAEERECRWYLGGCSQDGDCCKHLQCHSNYEWCVWDGTFSK
Physicochemical Analysis
C423H656N114O127S9
P
V
9659.09
5.06
12
13
37
-4
17.63
0.017
83.84
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
19855
205.56
21
Residue Composition
number
8
A
3
R
1
N
6
D
7
C
7
E
3
Q
5
G
3
H
1
I
8
L
6
K
2
M
3
F
0
P
6
S
2
T
3
W
2
Y
10
V
Amino Acid Distribution
A: 8 R: 3 N: 1 D: 6 C: 7 E: 7 Q: 3 G: 5 H: 3 I: 1 L: 8 K: 6 M: 2 F: 3 P: 0 S: 6 T: 2 W: 3 Y: 2 V: 10
Chemical Descriptors
86
C423H656N114O127S9
9659.09
5.06
-4
17.63
0.017
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-theraphotoxin-Hs2a blocks voltage-gated calcium channels (Cav) in adult cockroach DUM neurons. Reversibly paralyzes locusts and cockroaches, and causes death at high doses,. {ECO:0000269|PubMed:18234186}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-theraphotoxin-Hs2a blocks voltage-gated calcium channels (Cav) in adult cockroach DUM neurons. Reversibly paralyzes locusts and cockroaches, and causes death at high doses,..
Omega-theraphotoxin-Hs2a (Omega-TRTX-Hs2a) (Huwentoxin-5) (Huwentoxin-V) (HwTx-V) [Cleaved into: Omega-theraphotoxin-Hs2b (Omega-TRTX-Hs2b) (Mutant of huwentoxin-5) (Mutant of huwentoxin-V) (mHWTX-V)]
spider
Neurotoxin 10 (Hwtx-1) family, 17 (Hntx-9) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 17 (Hntx-9) subfamily
Omega-theraphotoxin-Hs2a (Omega-TRTX-Hs2a) (Huwentoxin-5) (Huwentoxin-V) (HwTx-V) [Cleaved into: Omega-theraphotoxin-Hs2b (Omega-TRTX-Hs2b) (Mutant of huwentoxin-5) (Mutant of huwentoxin-V) (mHWTX-V)]
TISSUE SPECIFICITY: Expressed by the venom gland.
spider