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Peptide record

TPDB34560

Neurotoxin Toxicity standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB34560
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 63-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKNTSILFILGLALLLVLAFEAQVGESDGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP
Physicochemical Analysis
C309H469N77O82S7
H
G
6799.01
7.62
6
5
27
+1
-0.57
0.297
79.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
23865
351.01
14
Residue Composition
number
6
A
1
R
1
N
1
D
6
C
4
E
1
Q
9
G
0
H
2
I
7
L
5
K
1
M
3
F
3
P
3
S
2
T
4
W
1
Y
3
V
Amino Acid Distribution
A: 6 R: 1 N: 1 D: 1 C: 6 E: 4 Q: 1 G: 9 H: 0 I: 2 L: 7 K: 5 M: 1 F: 3 P: 3 S: 3 T: 2 W: 4 Y: 1 V: 3
Chemical Descriptors
63
C309H469N77O82S7
6799.01
7.62
+1
-0.57
0.297
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selectively inhibits activation of voltage-gated sodium channels (VGSC) (Nav1.5/SCN5A) in rat cardiac myocytes, followed by shifting activated voltage in a depolarizing direction. The binding site on VGSC is suggested to be site 4 located at the extracellular S3-S4 loop of the channel. Also binds to voltage-gated potassium channels (Kv2.1/KCNB1). {ECO:0000269|PubMed:17150181}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Selectively inhibits activation of voltage-gated sodium channels (VGSC) (Nav1.5/SCN5A) in rat cardiac myocytes, followed by shifting activated voltage in a depolarizing direction. The binding site on VGSC is suggested to be site 4 located at the extracellular S3-S4 loop of the channel.
Beta/kappa-theraphotoxin-Cg1a (Beta/kappa-TRTX-Cg1a) (Jingzhaotoxin-3) (Jingzhaotoxin-III) (JZTX-III) (Peptide F5-20.38)
spider
Neurotoxin 10 (Hwtx-1) family, 44 (Jztx-4) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 44 (Jztx-4) subfamily
Beta/kappa-theraphotoxin-Cg1a (Beta/kappa-TRTX-Cg1a) (Jingzhaotoxin-3) (Jingzhaotoxin-III) (JZTX-III) (Peptide F5-20.38)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider