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Peptide record

TPDB34426

Neurotoxin Toxicity standard
87 amino acids
Basic Information
3D PDB MODEL
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TPDB34426
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 87-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKLTCVLVVLLLLLPYGDLITNNYIRGAARKVTPWRRNLKTRDVCDSLVGGHCIHNGCWCDQEAPHGNCCDTDGCTAAWWCPGTKWD
Physicochemical Analysis
C425H661N123O120S10
F
L
9734.28
7.47
12
8
32
+1
6.71
-0.103
84.02
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
30980
318.26
25
Residue Composition
number
5
A
5
R
5
N
7
D
9
C
1
E
1
Q
8
G
3
H
3
I
10
L
4
K
1
M
0
F
4
P
1
S
7
T
5
W
2
Y
6
V
Amino Acid Distribution
A: 5 R: 5 N: 5 D: 7 C: 9 E: 1 Q: 1 G: 8 H: 3 I: 3 L: 10 K: 4 M: 1 F: 0 P: 4 S: 1 T: 7 W: 5 Y: 2 V: 6
Chemical Descriptors
87
C425H661N123O120S10
9734.28
7.47
+1
6.71
-0.103
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin reversibly blocks voltage-gated sodium channel in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation. Has no effect on sodium channels of the two gastropod S.luhuanus and A.californica (which are not natural prey). {ECO:0000269|PubMed:21147978}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin reversibly blocks voltage-gated sodium channel in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation.
Mu-conotoxin cal12a (Conotoxin Cal 12.1.1a) (Conotoxin CalTx 12.1.1A)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Bromination Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:21147978}.
Additional Detail Fields 7 fields
Bromination Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Mu-conotoxin cal12a (Conotoxin Cal 12.1.1a) (Conotoxin CalTx 12.1.1A)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:21147978}.
cone snail