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Peptide record

TPDB34347

Neurotoxin Toxicity standard
87 amino acids
Basic Information
3D PDB MODEL
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TPDB34347
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 87-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKLSIFFVLFFIAIAYCQPEFLDDEEDEVEETLPVAEEGREKSCITWRNSCMHNDKGCCFPWSCVCWSQTVSRNSSRKEKKCQCRLW
Physicochemical Analysis
C452H686N120O134S11
E
10297.80
4.92
12
14
30
-3
19.96
-0.363
60.46
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
23990
232.96
27
Residue Composition
number
3
A
5
R
3
N
4
D
9
C
10
E
3
Q
2
G
1
H
4
I
5
L
6
K
2
M
6
F
3
P
8
S
3
T
4
W
1
Y
5
V
Amino Acid Distribution
A: 3 R: 5 N: 3 D: 4 C: 9 E: 10 Q: 3 G: 2 H: 1 I: 4 L: 5 K: 6 M: 2 F: 6 P: 3 S: 8 T: 3 W: 4 Y: 1 V: 5
Chemical Descriptors
87
C452H686N120O134S11
10297.80
4.92
-3
19.96
-0.363
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Modulates Cav2.1/CACNA1A voltage-gated calcium channels (P/Q-type currents) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons (PubMed:15590128, PubMed:17888477). At saturating concentrations (>10 nM) decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (PubMed:15590128, PubMed:17888477). In vivo, does not cause death when intravenously injected into mice (By similarity). In rat models, through its activity on Cav2.1/CACNA1A, has an ameliorative effect on memory defects provoked by hyperstimulation of N-methyl-D-aspartate receptors (NMDARs) in the hippocampus (By similarity). {ECO:0000250|UniProtKB:P0DRA9, ECO:0000269|PubMed:15590128, ECO:0000269|PubMed:17888477}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Alopecosa marikovskyi (Wolf spider) (Lycosa kazakhstanicus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Modulates Cav2.1/CACNA1A voltage-gated calcium channels (P/Q-type currents) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons (PubMed:15590128, PubMed:17888477). At saturating concentrations (>10 nM) decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (PubMed:15590128, PubMed:17888477).
Omega-lycotoxin-Am1a (Omega-LCTX-Am1a) (Lsp-1) (Omega-Lsp-IA) (Omega-lycotoxin-Gsp(267)1a) (Omega-LCTX-Gsp(267)1a)
spider
Neurotoxin omega-lctx family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17888477}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin omega-lctx family
Omega-lycotoxin-Am1a (Omega-LCTX-Am1a) (Lsp-1) (Omega-Lsp-IA) (Omega-lycotoxin-Gsp(267)1a) (Omega-LCTX-Gsp(267)1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17888477}.
spider