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Peptide record

TPDB34319

Neurotoxin Toxicity standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB34319
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 83-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKLCMTLLITAIAVVTFVVATQEESAEFNEVEESREDNCIAEDYGKCTWGGTKCCRGRPCRCSMIGTNCECTPRLIMEGLSFA
Physicochemical Analysis
C386H624N106O125S13
H
E
9166.62
4.50
8
12
30
-4
19.84
0.060
71.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
81.71
26
Residue Composition
number
6
A
5
R
3
N
2
D
9
C
10
E
1
Q
6
G
0
H
5
I
5
L
3
K
4
M
3
F
2
P
4
S
8
T
1
W
1
Y
5
V
Amino Acid Distribution
A: 6 R: 5 N: 3 D: 2 C: 9 E: 10 Q: 1 G: 6 H: 0 I: 5 L: 5 K: 3 M: 4 F: 3 P: 2 S: 4 T: 8 W: 1 Y: 1 V: 5
Chemical Descriptors
83
C386H624N106O125S13
9166.62
4.50
-4
19.84
0.060
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of voltage-gated Cav2.1/CACNA1A (P-type) calcium channels. Paralyzes insect by blocking neuromuscular transmission. {ECO:0000269|PubMed:8232218}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of voltage-gated Cav2.1/CACNA1A (P-type) calcium channels. Paralyzes insect by blocking neuromuscular transmission..
Omega-agatoxin-Aa4b (Omega-AGTX-Aa4b) (Omega-agatoxin IVB) (Omega-Aga-IVB) (Omega-agatoxin IVC) (Omega-Aga-IVC) (Omega-agatoxin tsukuba) (Omega-Aga-TK) (Omega-agatoxin-TK) (Omega-agatoxin-4B)
spider
Neurotoxin 02 (plectoxin) family, 03 (omega-agtx) subfamily
Evidence at protein level
3D-structure Calcium channel impairing toxin D-amino acid Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8216284, ECO:0000305|PubMed:8232218}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin D-amino acid Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 03 (omega-agtx) subfamily
Omega-agatoxin-Aa4b (Omega-AGTX-Aa4b) (Omega-agatoxin IVB) (Omega-Aga-IVB) (Omega-agatoxin IVC) (Omega-Aga-IVC) (Omega-agatoxin tsukuba) (Omega-Aga-TK) (Omega-agatoxin-TK) (Omega-agatoxin-4B)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8216284, ECO:0000305|PubMed:8232218}.
spider