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Peptide record

TPDB34318

Neurotoxin Toxicity standard
84 amino acids
Basic Information
3D PDB MODEL
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TPDB34318
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 84-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKLCILLVVLLITVVRAEEDILENEAEDISPAIKERSARGCIGRNESCKFDRHGCCWPWSCSCWNKEGQPESDVWCECSLKIGK
Physicochemical Analysis
C411H657N115O125S10
Y
E
9530.03
4.92
12
14
29
-3
23.02
-0.182
87.02
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22500
236.10
21
Residue Composition
number
4
A
5
R
3
N
4
D
9
C
10
E
1
Q
5
G
1
H
7
I
7
L
6
K
1
M
1
F
3
P
7
S
1
T
4
W
0
Y
5
V
Amino Acid Distribution
A: 4 R: 5 N: 3 D: 4 C: 9 E: 10 Q: 1 G: 5 H: 1 I: 7 L: 7 K: 6 M: 1 F: 1 P: 3 S: 7 T: 1 W: 4 Y: 0 V: 5
Chemical Descriptors
84
C411H657N115O125S10
9530.03
4.92
-3
23.02
-0.182
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). Causes paralysis in the posterior limbs and gradual decreases in movement and aggression during 24 hours at dose levels of 5 ug per mouse.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1). Causes paralysis in the posterior limbs and gradual decreases in movement and aggression during 24 hours at dose levels of 5 ug per mouse.
U7-ctenitoxin-Pn1a (U7-CNTX-Pn1a) (Neurotoxin Tx3-5) (PnTx3-5)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
U7-ctenitoxin-Pn1a (U7-CNTX-Pn1a) (Neurotoxin Tx3-5) (PnTx3-5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
spider