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Peptide record

TPDB34310

Neurotoxin Toxicity standard
112 amino acids
Basic Information
3D PDB MODEL
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TPDB34310
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 112-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKLLGIFLVASFAFVLSFGEEMIEGENPLEDQRAELTSCFPVGHECDGDASNCNCCGDDVYCGCGWGRWNCKCKVADQSYAYGICKDKVNCPNRHLWPAKVCKKPCRRNCGG
Physicochemical Analysis
C532H815N151O159S16
C
12383.20
6.06
15
14
37
-1
20.51
-0.266
59.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
21845
176.41
32
Residue Composition
number
7
A
5
R
7
N
7
D
14
C
7
E
2
Q
12
G
2
H
3
I
7
L
8
K
2
M
5
F
5
P
5
S
1
T
3
W
3
Y
7
V
Amino Acid Distribution
A: 7 R: 5 N: 7 D: 7 C: 14 E: 7 Q: 2 G: 12 H: 2 I: 3 L: 7 K: 8 M: 2 F: 5 P: 5 S: 5 T: 1 W: 3 Y: 3 V: 7
Chemical Descriptors
112
C532H815N151O159S16
12383.20
6.06
-1
20.51
-0.266
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversible inhibitor of neuronal sodium channels (Nav1.2/ SCN2A) that binds in proximity to site 1 and displays increasing affinity as the membrane potential is depolarized. Induces excitatory symptoms and spastic paralysis in mice. {ECO:0000269|PubMed:16505156, ECO:0000269|PubMed:16908187, ECO:0000269|PubMed:9723834}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Reversible inhibitor of neuronal sodium channels (Nav1.2/ SCN2A) that binds in proximity to site 1 and displays increasing affinity as the membrane potential is depolarized. Induces excitatory symptoms and spastic paralysis in mice..
Mu-ctenitoxin-Pn1a (Mu-CNTX-Pn1a) (Toxin Tx1) (PNTx1) (PhTx1)
spider
Neurotoxin 04 (omega-agtx) family, 02 (Tx1) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 02 (Tx1) subfamily
Mu-ctenitoxin-Pn1a (Mu-CNTX-Pn1a) (Toxin Tx1) (PNTx1) (PhTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
spider