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Peptide record

TPDB34308

Neurotoxin Toxicity standard
105 amino acids
Basic Information
3D PDB MODEL
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TPDB34308
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 105-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKLLFEGLLVLVLIAFVVAEFESDAEKWEALITQERACKGEGVKGCYYEADDWCCKKTPCKCPAWSHERECRCTQPCNPSCRGKRALMVDPETHRMLSLHRLSEE
Physicochemical Analysis
C524H828N146O154S13
E
12054.00
5.88
18
17
38
-2
31.11
-0.332
72.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
20105
166.79
24
Residue Composition
number
8
A
7
R
1
N
4
D
10
C
13
E
2
Q
5
G
3
H
2
I
11
L
8
K
3
M
3
F
5
P
5
S
4
T
3
W
2
Y
6
V
Amino Acid Distribution
A: 8 R: 7 N: 1 D: 4 C: 10 E: 13 Q: 2 G: 5 H: 3 I: 2 L: 11 K: 8 M: 3 F: 3 P: 5 S: 5 T: 4 W: 3 Y: 2 V: 6
Chemical Descriptors
105
C524H828N146O154S13
12054.00
5.88
-2
31.11
-0.332
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin active against insects (S.frugiperda larvae). May act on sodium (Nav) or calcium (Cav) channels.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Loxosceles intermedia (Brown spider)
Neurotoxin Ion channel impairing toxin
Toxin active against insects (S.frugiperda larvae). May act on sodium (Nav) or calcium (Cav) channels.
U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2)
spider
Neurotoxin 28 (Litx) family
Evidence at protein level
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15302533}.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 28 (Litx) family
U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15302533}.
spider