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Peptide record

TPDB34305

Neurotoxin Toxicity standard
123 amino acids
Basic Information
3D PDB MODEL
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TPDB34305
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 123-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKIVLVFVCTLYLAQATYLSEQDVNEVSEFLEALDQANEAASEMVEAAETEEARDWECLPLHSSCDNDCVCCKNHHCHCPYSNVSKLEKWLPEWAKIPDALKRCSCQRNDKDGKINTCDKYKN
Physicochemical Analysis
C604H939N165O196S13
E
14064.87
4.63
17
22
44
-9
39.52
-0.509
72.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
23085
164.13
39
Residue Composition
number
11
A
3
R
8
N
9
D
11
C
13
E
4
Q
1
G
4
H
3
I
11
L
10
K
2
M
2
F
4
P
8
S
4
T
3
W
4
Y
8
V
Amino Acid Distribution
A: 11 R: 3 N: 8 D: 9 C: 11 E: 13 Q: 4 G: 1 H: 4 I: 3 L: 11 K: 10 M: 2 F: 2 P: 4 S: 8 T: 4 W: 3 Y: 4 V: 8
Chemical Descriptors
123
C604H939N165O196S13
14064.87
4.63
-9
39.52
-0.509
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2) (By similarity). Is both paralytic and lethal when injected into lepidopteran larvae. Is not toxic to mice. {ECO:0000250, ECO:0000269|PubMed:11976325}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2) (By similarity). Is both paralytic and lethal when injected into lepidopteran larvae.
Omega-oxotoxin-Ot1a (Omega-OXTX-Ot1a) (Oxytoxin-1) (OxyTx1) (Tx-1)
spider
Spiderine family, Spiderine subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11976325}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Spiderine family, Spiderine subfamily
Omega-oxotoxin-Ot1a (Omega-OXTX-Ot1a) (Oxytoxin-1) (OxyTx1) (Tx-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11976325}.
spider