Back to search

Peptide record

TPDB34275

Neurotoxin Toxicity standard
70 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB34275
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 70-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKILEKALLENDSAAEEESRNLRTKRCARKRAWCEKTENCCCPMKCIYAWYNGQSSCDHTISTIWTSCPK
Physicochemical Analysis
C343H550N102O107S10
FV
C
8135.36
8.09
13
9
21
+3
18.88
-0.734
53.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
19980
245.59
26
Residue Composition
number
6
A
5
R
4
N
2
D
8
C
7
E
1
Q
1
G
1
H
4
I
4
L
7
K
2
M
0
F
2
P
6
S
5
T
3
W
2
Y
0
V
Amino Acid Distribution
A: 6 R: 5 N: 4 D: 2 C: 8 E: 7 Q: 1 G: 1 H: 1 I: 4 L: 4 K: 7 M: 2 F: 0 P: 2 S: 6 T: 5 W: 3 Y: 2 V: 0
Chemical Descriptors
70
C343H550N102O107S10
8135.36
8.09
+3
18.88
-0.734
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits tetrodotoxin-sensitive sodium channels (Nav) (By similarity). Intracranial injection into mice causes strong convulsions and death. Intrathorax injection into crickets causes paralysis prolonged for 2 minutes, followed by recovery. {ECO:0000250, ECO:0000269|PubMed:15246762}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits tetrodotoxin-sensitive sodium channels (Nav) (By similarity). Intracranial injection into mice causes strong convulsions and death.
Delta-hexatoxin-Mg1b (Delta-HXTX-Mg1b) (Delta-atracotoxin-9) (Neurotoxin magi-14)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15246762}.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Mg1b (Delta-HXTX-Mg1b) (Delta-atracotoxin-9) (Neurotoxin magi-14)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15246762}.
spider