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Peptide record

TPDB34247

Neurotoxin Toxicity standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB34247
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 83-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKGSAFAIILGLVVLCACSFAEDEQDQFASPNELLRSMFLESRHELIPEVEGRYCQKWMWTCDSERKCCEGYVCELWCKYNLG
Physicochemical Analysis
C423H645N109O125S11
E
9610.09
4.52
9
13
34
-5
14.46
-0.081
76.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
21470
223.41
23
Residue Composition
number
5
A
4
R
2
N
3
D
8
C
10
E
3
Q
5
G
1
H
3
I
9
L
4
K
3
M
4
F
2
P
6
S
1
T
3
W
3
Y
4
V
Amino Acid Distribution
A: 5 R: 4 N: 2 D: 3 C: 8 E: 10 Q: 3 G: 5 H: 1 I: 3 L: 9 K: 4 M: 3 F: 4 P: 2 S: 6 T: 1 W: 3 Y: 3 V: 4
Chemical Descriptors
83
C423H645N109O125S11
9610.09
4.52
-5
14.46
-0.081
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels of the subtype Kv4.1/KCND1 with high affinity and shows weak effects on Kv4.2/KCND2 and Kv2.1/KCNB1 subtypes. The toxin modifies the gating behavior of the channel and may interact with the S3-S4 extracellular loop. {ECO:0000269|PubMed:17631373, ECO:0000269|PubMed:18581053}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-gated potassium channels of the subtype Kv4.1/KCND1 with high affinity and shows weak effects on Kv4.2/KCND2 and Kv2.1/KCNB1 subtypes. The toxin modifies the gating behavior of the channel and may interact with the S3-S4 extracellular loop..
Kappa-theraphotoxin-Cg2a (Kappa-TRTX-Cg2a) (Jingzhaotoxin-12) (Jingzhaotoxin-45) (JZTX-45) (Jingzhaotoxin-XII) (JZTX-XII) (Peptide F4-20.99)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Kappa-theraphotoxin-Cg2a (Kappa-TRTX-Cg2a) (Jingzhaotoxin-12) (Jingzhaotoxin-45) (JZTX-45) (Jingzhaotoxin-XII) (JZTX-XII) (Peptide F4-20.99)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider