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Peptide record

TPDB34177

Neurotoxin Toxicity standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB34177
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 83-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKASVFAVILGLVVLCACSFAEDEQDQFVSPNELLKSMFVESRHEFTPEVEGRYCQKWMWTCDSKRACCEGLRCKLWCRKIIG
Physicochemical Analysis
C423H661N113O119S11
CE
9586.25
6.72
12
11
34
-0
15.00
0.019
77.47
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18490
192.88
21
Residue Composition
number
5
A
5
R
1
N
3
D
8
C
8
E
3
Q
4
G
1
H
3
I
7
L
6
K
3
M
5
F
2
P
6
S
2
T
3
W
1
Y
7
V
Amino Acid Distribution
A: 5 R: 5 N: 1 D: 3 C: 8 E: 8 Q: 3 G: 4 H: 1 I: 3 L: 7 K: 6 M: 3 F: 5 P: 2 S: 6 T: 2 W: 3 Y: 1 V: 7
Chemical Descriptors
83
C423H661N113O119S11
9586.25
6.72
-0
15.00
0.019
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This gating-modifier toxin shows an important inhibitory activity on sodium channels (PubMed:29723257). It is very active on Nav1.7/SCN9A (IC(50)~0.6 nM), and also shows activity on Nav1.3/SCN3A (IC(50)=292 nM), Nav1.4/SCN4A (IC(50)=2.2-159 nM), and Nav1.5/SCN5A (IC(50)=2.3-2.9 uM) (PubMed:25055801, PubMed:29723257). It has also been shown to inhibit tetrodotoxin (TTX)-resistant (IC(50)=27.6 nM) and TTX-sensitive (IC(50)=30.2 nM) sodium channels in rat dorsal root ganglion neurons (PubMed:17157888). Lower inhibitory activity has also been shown on potassium channels: Kv4.2/KCND2 (IC(50)=604.2 nM), Kv4.3/KCND3 (IC(50)=425.1 nM), and Kv2.1/KCNB1 (IC(50)=14.3 uM) (PubMed:17150181, PubMed:17157888, PubMed:20571743). It binds to phospholipid membranes. Like its analog AM-8145, it may act by interacting only with the second voltage-sensor domain of Nav1.7/SCN9A (Probable). {ECO:0000269|PubMed:17150181, ECO:0000269|PubMed:17157888, ECO:0000269|PubMed:18581053, ECO:0000269|PubMed:20571743, ECO:0000269|PubMed:29723257}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
This gating-modifier toxin shows an important inhibitory activity on sodium channels (PubMed:29723257). It is very active on Nav1.7/SCN9A (IC(50)~0.6 nM), and also shows activity on Nav1.3/SCN3A (IC(50)=292 nM), Nav1.4/SCN4A (IC(50)=2.2-159 nM), and Nav1.5/SCN5A (IC(50)=2.3-2.9 uM) (PubMed:25055801, PubMed:29723257).
Beta/kappa-theraphotoxin-Cg2a (Beta/kappa-TRTX-Cg2a) (Beta-theraphotoxin-Cj2a) (Jingzhaotoxin-5) (Jingzhaotoxin-V) (JZTX-V) (Peptide F8-15.73)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17157888}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Beta/kappa-theraphotoxin-Cg2a (Beta/kappa-TRTX-Cg2a) (Beta-theraphotoxin-Cj2a) (Jingzhaotoxin-5) (Jingzhaotoxin-V) (JZTX-V) (Peptide F8-15.73)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17157888}.
spider