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Peptide record

TPDB34173

Neurotoxin Toxicity standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB34173
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 83-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKASMYLALAGLVLLFVVGYASESEEKEFPRELLSKIFAVDDFKGEERGCKGFGDSCTPGKNERCPNYACSSKHKWCKVYLGK
Physicochemical Analysis
C414H643N107O120S7
Q
K
9263.72
8.12
14
11
32
+2
18.08
-0.296
66.99
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11710
126.41
19
Residue Composition
number
6
A
3
R
2
N
3
D
5
C
8
E
0
Q
8
G
1
H
1
I
8
L
10
K
2
M
5
F
3
P
7
S
1
T
1
W
4
Y
5
V
Amino Acid Distribution
A: 6 R: 3 N: 2 D: 3 C: 5 E: 8 Q: 0 G: 8 H: 1 I: 1 L: 8 K: 10 M: 2 F: 5 P: 3 S: 7 T: 1 W: 1 Y: 4 V: 5
Chemical Descriptors
83
C414H643N107O120S7
9263.72
8.12
+2
18.08
-0.296
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Lethal neurotoxin. Selectively blocks tetrodotoxin-sensitive voltage-gated sodium channels (Nav). Does not affect tetrodotoxin-resistant voltage-gated sodium channels or calcium channels (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Lethal neurotoxin. Selectively blocks tetrodotoxin-sensitive voltage-gated sodium channels (Nav).
Mu-theraphotoxin-Hhn2g (Mu-TRTX-Hhn2g) (Hainantoxin-III-14) (HNTX-III-14)
spider
Neurotoxin 10 (Hwtx-1) family, 15 (Hntx-3) subfamily
Evidence at transcript level
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Neurotoxin 10 (Hwtx-1) family, 15 (Hntx-3) subfamily
Mu-theraphotoxin-Hhn2g (Mu-TRTX-Hhn2g) (Hainantoxin-III-14) (HNTX-III-14)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider