Back to search

Peptide record

TPDB34169

Neurotoxin Toxicity standard
86 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB34169
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 86-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKASMFLALTGLALLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCKYEIGK
Physicochemical Analysis
C410H652N112O131S9
S
9534.90
5.70
12
12
30
-1
21.14
-0.266
72.56
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
92.87
27
Residue Composition
number
5
A
3
R
5
N
3
D
7
C
9
E
1
Q
6
G
1
H
1
I
10
L
8
K
2
M
4
F
1
P
11
S
1
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 5 R: 3 N: 5 D: 3 C: 7 E: 9 Q: 1 G: 6 H: 1 I: 1 L: 10 K: 8 M: 2 F: 4 P: 1 S: 11 T: 1 W: 1 Y: 2 V: 5
Chemical Descriptors
86
C410H652N112O131S9
9534.90
5.70
-1
21.14
-0.266
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) with an IC(50) of 44.6 nM. Does not affect tetrodotoxin-resistant voltage-gated sodium channels or calcium channels. {ECO:0000269|PubMed:12518233, ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) with an IC(50) of 44.6 nM.
Mu-theraphotoxin-Hhn1b 3 (Mu-TRTX-Hhn1b) (Hainantoxin-4.3) (Hainantoxin-IV.3) (HnTx-IV.3) (Peptide F8-18.88)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Hhn1b 3 (Mu-TRTX-Hhn1b) (Hainantoxin-4.3) (Hainantoxin-IV.3) (HnTx-IV.3) (Peptide F8-18.88)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.
spider