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Peptide record

TPDB34138

Neurotoxin Toxicity standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB34138
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 83-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKASMFLALAGLVLLFVVCYASESEEKEFPRELISKIFAVDDFKGEVRECKGFGKSCVPGKNECCSGYACNSRDKWCKVLLGK
Physicochemical Analysis
C410H649N105O117S9
QHT
K
9209.84
7.92
13
11
34
+2
16.62
0.055
78.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
96.15
18
Residue Composition
number
6
A
3
R
2
N
3
D
7
C
8
E
0
Q
7
G
0
H
2
I
8
L
10
K
2
M
6
F
2
P
7
S
0
T
1
W
2
Y
7
V
Amino Acid Distribution
A: 6 R: 3 N: 2 D: 3 C: 7 E: 8 Q: 0 G: 7 H: 0 I: 2 L: 8 K: 10 M: 2 F: 6 P: 2 S: 7 T: 0 W: 1 Y: 2 V: 7
Chemical Descriptors
83
C410H649N105O117S9
9209.84
7.92
+2
16.62
0.055
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly blocks the rat SCN2A/SCN1B (Nav1.2/beta-1) sodium channel (IC(50)=68 uM) and the insect sodium channel para/tipE (IC(50)=4.3 uM), without altering the activation or inactivation kinetics (depressant toxin). {ECO:0000269|PubMed:14675784, ECO:0000269|PubMed:26429937}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Weakly blocks the rat SCN2A/SCN1B (Nav1.2/beta-1) sodium channel (IC(50)=68 uM) and the insect sodium channel para/tipE (IC(50)=4.3 uM), without altering the activation or inactivation kinetics (depressant toxin)..
Mu-theraphotoxin-Hhn2b 3 (Mu-TRTX-Hhn2b) (Hainantoxin-I) (HnTx-I) (Peptide F5-19.03)
spider
Neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14675784}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily
Mu-theraphotoxin-Hhn2b 3 (Mu-TRTX-Hhn2b) (Hainantoxin-I) (HnTx-I) (Peptide F5-19.03)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14675784}.
spider