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Peptide record

TPDB34135

Neurotoxin Toxicity standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB34135
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 86-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKASMFLALAGLDLLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCKYEIGK
Physicochemical Analysis
C410H650N112O132S9
T
S
9548.88
5.18
12
13
30
-2
22.23
-0.299
72.56
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
92.73
26
Residue Composition
number
5
A
3
R
5
N
4
D
7
C
9
E
1
Q
6
G
1
H
1
I
10
L
8
K
2
M
4
F
1
P
11
S
0
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 5 R: 3 N: 5 D: 4 C: 7 E: 9 Q: 1 G: 6 H: 1 I: 1 L: 10 K: 8 M: 2 F: 4 P: 1 S: 11 T: 0 W: 1 Y: 2 V: 5
Chemical Descriptors
86
C410H650N112O132S9
9548.88
5.18
-2
22.23
-0.299
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) with an IC(50) of 44.6 nM. Does not affect tetrodotoxin-resistant voltage-gated sodium channels or calcium channels. {ECO:0000269|PubMed:12518233, ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) with an IC(50) of 44.6 nM.
Mu-theraphotoxin-Hhn1b 2 (Mu-TRTX-Hhn1b) (Hainantoxin-4.2) (Hainantoxin-IV.2) (HnTx-IV.2) (Peptide F8-18.88)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Hhn1b 2 (Mu-TRTX-Hhn1b) (Hainantoxin-4.2) (Hainantoxin-IV.2) (HnTx-IV.2) (Peptide F8-18.88)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.
spider