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Peptide record

TPDB34133

Neurotoxin Toxicity standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB34133
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 86-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKASMFLALAGLALLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCKYEIGK
Physicochemical Analysis
C409H650N112O130S9
T
S
9504.87
5.70
12
12
31
-1
20.83
-0.237
73.72
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
93.16
26
Residue Composition
number
6
A
3
R
5
N
3
D
7
C
9
E
1
Q
6
G
1
H
1
I
10
L
8
K
2
M
4
F
1
P
11
S
0
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 6 R: 3 N: 5 D: 3 C: 7 E: 9 Q: 1 G: 6 H: 1 I: 1 L: 10 K: 8 M: 2 F: 4 P: 1 S: 11 T: 0 W: 1 Y: 2 V: 5
Chemical Descriptors
86
C409H650N112O130S9
9504.87
5.70
-1
20.83
-0.237
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that selectively inhibits neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) (IC(50)=44.6 nM) (PubMed:12518233, PubMed:14512091). It is active on Nav1.2/SCN2A (IC(50)=22.4 nM), Nav1.6/SCN8A (IC(50)=50.1 nM) and Nav1.7/SCN9A (IC(50)=48.9 nM) (PubMed:29703751). It shows low affinity for lipid bilayers (PubMed:29703751). {ECO:0000269|PubMed:12518233, ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091, ECO:0000269|PubMed:29703751}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin that selectively inhibits neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) (IC(50)=44.6 nM) (PubMed:12518233, PubMed:14512091). It is active on Nav1.2/SCN2A (IC(50)=22.4 nM), Nav1.6/SCN8A (IC(50)=50.1 nM) and Nav1.7/SCN9A (IC(50)=48.9 nM) (PubMed:29703751).
Mu-theraphotoxin-Hhn1b 1 (Mu-TRTX-Hhn1b) (Hainantoxin-4) (Hainantoxin-IV) (HnTx-IV) (Peptide F8-18.88)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Hhn1b 1 (Mu-TRTX-Hhn1b) (Hainantoxin-4) (Hainantoxin-IV) (HnTx-IV) (Peptide F8-18.88)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12827284, ECO:0000269|PubMed:14512091}.
spider