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Peptide record

TPDB34131

Neurotoxin Toxicity standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB34131
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 86-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKASMFLALAGLALLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNPSNDQCCKSSNLVCSRKHRRCKYEIGK
Physicochemical Analysis
C404H652N114O130S9
TW
S
9474.85
6.75
13
12
30
-0
23.49
-0.279
73.72
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
35.41
26
Residue Composition
number
6
A
4
R
5
N
3
D
7
C
9
E
1
Q
6
G
1
H
1
I
10
L
8
K
2
M
4
F
1
P
11
S
0
T
0
W
2
Y
5
V
Amino Acid Distribution
A: 6 R: 4 N: 5 D: 3 C: 7 E: 9 Q: 1 G: 6 H: 1 I: 1 L: 10 K: 8 M: 2 F: 4 P: 1 S: 11 T: 0 W: 0 Y: 2 V: 5
Chemical Descriptors
86
C404H652N114O130S9
9474.85
6.75
-0
23.49
-0.279
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav). Does not affect tetrodotoxin-resistant voltage-gated sodium channels or calcium channels. {ECO:0000250|UniProtKB:D2Y232}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav).
Mu-theraphotoxin-Hhn1c (Mu-TRTX-Hhn1c) (Hainantoxin-IV-2) (HNTX-IV-2)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at transcript level
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Hhn1c (Mu-TRTX-Hhn1c) (Hainantoxin-IV-2) (HNTX-IV-2)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider