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Peptide record

TPDB34121

Neurotoxin Toxicity standard
79 amino acids
Basic Information
3D PDB MODEL
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TPDB34121
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 79-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKAPATTLILVMSLISVLWATPDLEEGDLLAELGDLIATDDEYPMKPEERGCKLTFWKCKNKKECCGWNACALGICMPR
Physicochemical Analysis
C388H623N97O114S10
QH
L
8791.40
4.59
9
12
33
-3
14.51
0.023
90.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18365
208.90
16
Residue Composition
number
7
A
2
R
2
N
5
D
6
C
7
E
0
Q
5
G
0
H
4
I
11
L
7
K
4
M
1
F
5
P
2
S
5
T
3
W
1
Y
2
V
Amino Acid Distribution
A: 7 R: 2 N: 2 D: 5 C: 6 E: 7 Q: 0 G: 5 H: 0 I: 4 L: 11 K: 7 M: 4 F: 1 P: 5 S: 2 T: 5 W: 3 Y: 1 V: 2
Chemical Descriptors
79
C388H623N97O114S10
8791.40
4.59
-3
14.51
0.023
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insect and vertebrate active toxin. Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected. Competes for binding at site 3 of the insect sodium channel. Causes temporary paralysis when injected into lepidopteran larvae at 8.6 nmol/g. A low intracranial injection dose into mice causes lacrimation, closure of the eyes and sweating. A high injection dose causes extensive lacrimation and death. {ECO:0000269|PubMed:12860384}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insect and vertebrate active toxin. Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected.
Beta-hexatoxin-Mg1a (Beta-HXTX-Mg1a) (Neurotoxin magi-5)
spider
Neurotoxin 15 family, 01 (magi-5) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 15 family, 01 (magi-5) subfamily
Beta-hexatoxin-Mg1a (Beta-HXTX-Mg1a) (Neurotoxin magi-5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
spider