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Peptide record

TPDB34120

Neurotoxin Toxicity standard
81 amino acids
Basic Information
3D PDB MODEL
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TPDB34120
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 81-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKAPATIVILIMSLISVLWATADTEDGNLLFPIEDFIRKFDEYPVQPKERSCKLTFWRCKKDKECCGWNICTGLCIPPGKK
Physicochemical Analysis
C420H665N105O114S8
H
K
9266.02
8.01
12
10
32
+2
13.06
-0.035
87.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18365
198.20
18
Residue Composition
number
4
A
3
R
2
N
5
D
6
C
5
E
1
Q
4
G
0
H
8
I
7
L
9
K
2
M
4
F
6
P
3
S
5
T
3
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 3 N: 2 D: 5 C: 6 E: 5 Q: 1 G: 4 H: 0 I: 8 L: 7 K: 9 M: 2 F: 4 P: 6 S: 3 T: 5 W: 3 Y: 1 V: 3
Chemical Descriptors
81
C420H665N105O114S8
9266.02
8.01
+2
13.06
-0.035
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated sodium channels (Nav) (By similarity). Intracranial injection into mice causes lacrimation, slow breathing and death. Intrathorax injection into crickets causes death. {ECO:0000250, ECO:0000269|PubMed:15246762}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks voltage-gated sodium channels (Nav) (By similarity). Intracranial injection into mice causes lacrimation, slow breathing and death.
U12-hexatoxin-Mg1a (U12-HXTX-Mg1a) (Neurotoxin magi-11) (Peptide toxin 5)
spider
Neurotoxin 15 family, 01 (magi-5) subfamily
Evidence at protein level
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15246762}.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 15 family, 01 (magi-5) subfamily
U12-hexatoxin-Mg1a (U12-HXTX-Mg1a) (Neurotoxin magi-11) (Peptide toxin 5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15246762}.
spider