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Peptide record

TPDB34098

Neurotoxin Toxicity standard
73 amino acids
Basic Information
3D PDB MODEL
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TPDB34098
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 73-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MIMRMTLTLFVLVVMTAASASGDALTEAKRIPYCGQTGAECYSWCIKQDLSKDWCCDFVKTIARLPPAHICSQ
Physicochemical Analysis
C355H567N93O102S10
N
A
8090.57
7.63
8
6
33
+1
4.73
0.305
85.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14355
177.43
22
Residue Composition
number
8
A
3
R
0
N
4
D
6
C
2
E
3
Q
3
G
1
H
5
I
6
L
4
K
4
M
2
F
3
P
5
S
6
T
2
W
2
Y
4
V
Amino Acid Distribution
A: 8 R: 3 N: 0 D: 4 C: 6 E: 2 Q: 3 G: 3 H: 1 I: 5 L: 6 K: 4 M: 4 F: 2 P: 3 S: 5 T: 6 W: 2 Y: 2 V: 4
Chemical Descriptors
73
C355H567N93O102S10
8090.57
7.63
+1
4.73
0.305
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that induces excitatory symptoms in mice following intracranial administration. No symptoms are observed after intraperitoneal and intravenous (tail vein) injections. {ECO:0000269|PubMed:22399292}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus imperialis (Imperial cone)
Neurotoxin
Neurotoxin that induces excitatory symptoms in mice following intracranial administration. No symptoms are observed after intraperitoneal and intravenous (tail vein) injections..
Conotoxin im23b (Conopeptide im009) (Im23.2) (U1-CTX-Ci1b)
cone snail
Conotoxin K superfamily
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:22399292, ECO:0000305|PubMed:30893765}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Conotoxin K superfamily
Conotoxin im23b (Conopeptide im009) (Im23.2) (U1-CTX-Ci1b)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:22399292, ECO:0000305|PubMed:30893765}.
cone snail