Back to search

Peptide record

TPDB34065

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB34065
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
MICYSHKTPQPSATIGCEEKTCYKKSVRKL
Physicochemical Analysis
C148H245N41O44S4
NDFW
K
3431.06
9.47
7
2
8
+4
8.95
-0.673
52.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3105
90.50
12
Residue Composition
number
1
A
1
R
0
N
0
D
3
C
2
E
1
Q
1
G
1
H
2
I
1
L
5
K
1
M
0
F
2
P
3
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 3 E: 2 Q: 1 G: 1 H: 1 I: 2 L: 1 K: 5 M: 1 F: 0 P: 2 S: 3 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
30
C148H245N41O44S4
3431.06
9.47
+4
8.95
-0.673
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels (Kv). This is the slowly inactivating phase of potassium efflux which is blocked by this toxin. {ECO:0000269|PubMed:1304870}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels (Kv). This is the slowly inactivating phase of potassium efflux which is blocked by this toxin..
Dendrotoxin B (DTX-B)
snake
Three-finger toxin family, Short-chain subfamily, Orphan group XI sub-subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Orphan group XI sub-subfamily
Dendrotoxin B (DTX-B)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake