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Peptide record

TPDB33579

Leu-Valorphin-Arg (Hemorphin-9 LVV-hemorphin 6) - ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB33579
Leu-Valorphin-Arg (Hemorphin-9 LVV-hemorphin 6) - ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide Toxicity
Cardiometabolic peptides Toxicity and safety peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LVVYPWTQR
Physicochemical Analysis
C56H84N14O13
ANDCEGHIKMFS
V
1161.37
9.88
1
0
5
+1
-1.23
-0.033
107.78
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
6990
601.88
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
9
C56H84N14O13
1161.37
9.88
+1
-1.23
-0.033
1161.3488
1160.6323
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lantz I., Glämsta E.-L., Tälback L., Nyberg F.
Hemorphins derived from hemoglobin have an inhibitory action on angiotensin-converting enzyme activity. FEBS Lett., 287, 39-41, 1991
1991
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O)[C@@]([H])(C)O InChI=InChI=1S/C56H84N14O13/c1-28(2)24-36(57)47(74)67-45(30(5)6)52(79)68-44(29(3)4)51(78)66-41(25-32-16-18-34(72)19-17-32)54(81)70-23-11-15-42(70)50(77)65-40(26-33-27-62-37-13-9-8-12-35(33)37)49(76)69-46(31(7)71)53(80)63-38(20-21-43(58)73)48(75)64-39(55(82)83)14-10-22-61-56(59)60/h8-9,12-13,16-19,27-31,36,38-42,44-46,62,71-72H,10-11,14-15,20-26,57H2,1-7H3,(H2,58,73)(H,63,80)(H,64,75)(H,65,77)(H,66,78)(H,67,74)(H,68,79)(H,69,76)(H,82,83)(H4,59,60,61)/t31-,36+,38+,39+,40+,41+,42+,44+,45+,46+/m1/s1 InChIKey=TYDMAYCCXBUMFX-ZAIVSCQOSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2862), the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BRENDA database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Lantz I., Glämsta E.-L., Tälback L., Nyberg F.
Hemorphins derived from hemoglobin have an inhibitory action on angiotensin-converting enzyme activity. FEBS Lett., 287, 39-41, 1991
1991
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O)[C@@]([H])(C)O InChI=InChI=1S/C56H84N14O13/c1-28(2)24-36(57)47(74)67-45(30(5)6)52(79)68-44(29(3)4)51(78)66-41(25-32-16-18-34(72)19-17-32)54(81)70-23-11-15-42(70)50(77)65-40(26-33-27-62-37-13-9-8-12-35(33)37)49(76)69-46(31(7)71)53(80)63-38(20-21-43(58)73)48(75)64-39(55(82)83)14-10-22-61-56(59)60/h8-9,12-13,16-19,27-31,36,38-42,44-46,62,71-72H,10-11,14-15,20-26,57H2,1-7H3,(H2,58,73)(H,63,80)(H,64,75)(H,65,77)(H,66,78)(H,67,74)(H,68,79)(H,69,76)(H,82,83)(H4,59,60,61)/t31-,36+,38+,39+,40+,41+,42+,44+,45+,46+/m1/s1 InChIKey=TYDMAYCCXBUMFX-ZAIVSCQOSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2862), the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BRENDA database
Additional Detail Fields 1 fields
9