TPDB

3D PDB MODEL

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TPDB ID TPDB33578

Peptide_Name

ACE inhibitor - LVV-hemorphin-5

Activity

ACE inhibitors Neuropeptide Toxicity

Activity_category_statistics

Cardiometabolic peptides Toxicity and safety peptides Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors, Neuropeptide, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LVVYPWTQ

FASTA

>TPDB33578|ACE inhibitors;Neuropeptide;Toxicity|length=8
LVVYPWTQ

Formula C50H72N10O12

Absent Amino Acids ARNDCEGHIKMFS

Common Amino Acids V

Mass 1005.18

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 5

Net Charge -0

Boman Index -2.04

Hydrophobicity 0.525

Aliphatic Index 121.25

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 695.40

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

1

T

1

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 2

Length

8

Formula

C50H72N10O12

Mass

1005.18

PI

5.94

Net Charge

-0

Boman Index

-2.04

Hydrophobicity

0.525

Chemical_Mass

1005.1636

Monoisotopic_Mass

1004.5314

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 72.80 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zhao Q., Piot J. M.

Title

Investigation of inhibition angiotensin-converting enzyme (ACE) activity and opioid activity of two hemorphins, LVV-hemorphin-5 and VV-hemorphin-5, isolated from a defined peptic hydrolysate of bovine hemoglobin. Neuropeptides, 31, 147-153, 1997

Year 1997

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C4=CC=CC=C34)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)O.N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N7[C@@H](CCC7)C(=O)N[C@@H](CC8=C[N]([H])C9=CC=CC=C89)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O InChI=1S/C65H93N15O14.C50H72N10O12/c1-34(2)29-43(66)55(84)77-53(36(5)6)61(90)78-52(35(3)4)60(89)75-48(30-39-21-23-41(82)24-22-39)63(92)80-28-14-20-50(80)59(88)74-47(32-40-33-71-44-18-12-11-17-42(40)44)58(87)79-54(37(7)81)62(91)73-46(25-26-51(67)83)57(86)72-45(19-13-27-70-65(68)69)56(85)76-49(64(93)94)31-38-15-9-8-10-16-38 1-25(2)21-33(51)43(64)57-41(27(5)6)47(68)58-40(26(3)4)46(67)56-37(22-29-14-16-31(62)17-15-29)49(70)60-20-10-13-38(60)45(66)55-36(23-30-24-53-34-12-9-8-11-32(30)34)44(65)59-42(28(7)61)48(69)54-35(50(71)72)18-19-39(52)63/h8-12,15-18,21-24,33-37,43,45-50,52-54,71,81-82H,13-14,19-20,25-32,66H2,1-7H3,(H2,67,83)(H,72,86)(H,73,91)(H,74,88)(H,75,89)(H,76,85)(H,77,84)(H,78,90)(H,79,87)(H,93,94)(H4,68,69,70) 8-9,11-12,14-17,24-28,33,35-38,40-42,53,61-62H,10,13,18-23,51H2,1-7H3,(H2,52,63)(H,54,69)(H,55,66)(H,56,67)(H,57,64)(H,58,68)(H,59,65)(H,71,72)/t37-,43+,45+,46+,47+,48+,49+,50+,52+,53+,54+ 28-,33+,35+,36+,37+,38+,40+,41+,42+/m11/s1 InChIKey: VGPAXAQBONOOQM-XSYCEYQRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2974), the EROP-Moscow database

Number_of_Residues

8