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Peptide record

TPDB33523

Neurotoxin Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB33523
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 11-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LTCYKGYRDTV
Physicochemical Analysis
C58H91N15O18S1
ANEQHIMFPSW
TY
1318.51
8.82
2
1
4
+1
0.71
-0.527
61.82
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
226.01
5
Residue Composition
number
0
A
1
R
0
N
1
D
1
C
0
E
0
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
11
C58H91N15O18S1
1318.51
8.82
+1
0.71
-0.527
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and hinders acetylcholine binding to the receptor, thereby impairing neuromuscular and neuronal transmission. {ECO:0000250|UniProtKB:P60615, ECO:0000269|PubMed:10518793}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pseudonaja textilis (Eastern brown snake)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and hinders acetylcholine binding to the receptor, thereby impairing neuromuscular and neuronal transmission..
Short neurotoxin N1 (Alpha-neurotoxin)
snake
Three-finger toxin family, Short-chain subfamily, Type III alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Reference proteome Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Reference proteome Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type III alpha-neurotoxin sub-subfamily
Short neurotoxin N1 (Alpha-neurotoxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake