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Peptide record

TPDB33521

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB33521
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LTCYKGYHDTVVCKP
Physicochemical Analysis
C77H119N19O22S2
ARNEQIMFSW
CKTYV
1727.03
8.27
3
1
5
+1
2.13
-0.220
64.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
3105
179.79
6
Residue Composition
number
0
A
0
R
0
N
1
D
2
C
0
E
0
Q
1
G
1
H
0
I
1
L
2
K
0
M
0
F
1
P
0
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 2 M: 0 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
15
C77H119N19O22S2
1727.03
8.27
+1
2.13
-0.220
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and hinders acetylcholine binding to the receptor, thereby impairing neuromuscular and neuronal transmission. {ECO:0000250|UniProtKB:P60615, ECO:0000269|PubMed:10518793}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pseudonaja textilis (Eastern brown snake)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and hinders acetylcholine binding to the receptor, thereby impairing neuromuscular and neuronal transmission..
Short neurotoxin N2 (Alpha-neurotoxin)
snake
Three-finger toxin family, Short-chain subfamily, Type III alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Reference proteome Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Reference proteome Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type III alpha-neurotoxin sub-subfamily
Short neurotoxin N2 (Alpha-neurotoxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake