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Peptide record

TPDB33499

Neurotoxin Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB33499
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 40-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
LTCVKSNSIWFITSENCPAGQNLCFKRWQYISPRMYDFTR
Physicochemical Analysis
C216H324N58O59S4
H
S
4805.54
9.08
5
2
15
+3
-0.14
-0.355
58.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
14105
293.52
17
Residue Composition
number
1
A
3
R
3
N
1
D
3
C
1
E
2
Q
1
G
0
H
3
I
2
L
2
K
1
M
3
F
2
P
4
S
3
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 3 D: 1 C: 3 E: 1 Q: 2 G: 1 H: 0 I: 3 L: 2 K: 2 M: 1 F: 3 P: 2 S: 4 T: 3 W: 2 Y: 2 V: 1
Chemical Descriptors
40
C216H324N58O59S4
4805.54
9.08
+3
-0.14
-0.355
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists. {ECO:0000269|PubMed:10665800}.

Target

acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists..
Muscarinic m1-toxin4
snake
Three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily
Muscarinic m1-toxin4
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake