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Peptide record

TPDB33399

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB33399
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LPPCCTPPKKHCPAPACKYKPCCKS
Physicochemical Analysis
C117H190N32O29S6
RNDEQGIMFWV
P
2701.35
8.88
6
0
4
+5
6.05
-0.572
23.60
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1865
69.04
9
Residue Composition
number
2
A
0
R
0
N
0
D
6
C
0
E
0
Q
0
G
1
H
0
I
1
L
5
K
0
M
0
F
7
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 5 M: 0 F: 0 P: 7 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C117H190N32O29S6
2701.35
8.88
+5
6.05
-0.572
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Kappa-conotoxins inhibits voltage-gated potassium channels. This toxin dose-dependently and reversibly inhibits the Kv1.2/KCNA2 channel in mammalia. Does not exert protective effect on cardiac tissue when administered after an ischemic event. {ECO:0000269|PubMed:20220134}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Kappa-conotoxins inhibits voltage-gated potassium channels. This toxin dose-dependently and reversibly inhibits the Kv1.2/KCNA2 channel in mammalia.
Kappa-conotoxin RIIIJ (Kappa-M-RIIIJ)
cone snail
Conotoxin M superfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20220134}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Kappa-conotoxin RIIIJ (Kappa-M-RIIIJ)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20220134}.
cone snail