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Peptide record

TPDB33361

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB33361
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LNKRCAGIGSFCGLPGLVDCCSGRCFIVCLP
Physicochemical Analysis
C137H225N39O37S6
EQHMTWY
C
3202.89
8.02
3
1
11
+2
-1.12
0.913
97.42
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
375
11.71
9
Residue Composition
number
1
A
2
R
1
N
1
D
6
C
0
E
0
Q
5
G
0
H
2
I
4
L
1
K
0
M
2
F
2
P
2
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 4 K: 1 M: 0 F: 2 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
31
C137H225N39O37S6
3202.89
8.02
+2
-1.12
0.913
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This toxin activates voltage-gated sodium channels. It shifts the voltage-dependence of activation to more hyperpolarized potentials but has only little effect on channel inactivation. It is active on Nav1.3/SCN3A (EC(50)=3.98 nM), Nav1.4/SCN4A (EC(50)=4.99 nM), Nav1.6/SCN8A (EC(50)=1.27 nM) and Nav1.7/SCN9A (EC(50)=2.42 nM) voltage-gated sodium channels. In vivo, it induces nocifensive or pain-like behaviors in mice when injected intraplantarly. {ECO:0000250|UniProtKB:P0DL67}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus eburneus (Ivory cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
This toxin activates voltage-gated sodium channels. It shifts the voltage-dependence of activation to more hyperpolarized potentials but has only little effect on channel inactivation.
Delta-conotoxin-like ErVIA
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:25848010}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin-like ErVIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:25848010}.
cone snail