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Peptide record

TPDB33327

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB33327
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LKDGYPTNSKGCKISGCLPGENKFCLNECQ
Physicochemical Analysis
C137H220N38O45S4
ARHMWV
CGK
3247.72
7.84
4
3
6
+1
7.39
-0.660
52.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1740
53.58
12
Residue Composition
number
0
A
0
R
3
N
1
D
4
C
2
E
1
Q
4
G
0
H
1
I
3
L
4
K
0
M
1
F
2
P
2
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 3 D: 1 C: 4 E: 2 Q: 1 G: 4 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
30
C137H220N38O45S4
3247.72
7.84
+1
7.39
-0.660
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and inhibits both the activation and inactivation of the activated channels, thereby blocking neuronal transmission. {ECO:0000269|PubMed:9248005}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Babycurus centrurimorphus (East African scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and inhibits both the activation and inactivation of the activated channels, thereby blocking neuronal transmission..
Babycurus-toxin 1 (BcTx1)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Babycurus-toxin 1 (BcTx1)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion