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Peptide record

TPDB33321

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB33321
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LKCYSSRTETMTCPEGKDKCEKYAV
Physicochemical Analysis
C120H196N32O41S4
NQHIFW
K
2871.31
8.00
5
4
6
+1
9.71
-0.928
31.20
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
3105
108.14
10
Residue Composition
number
1
A
1
R
0
N
1
D
3
C
3
E
0
Q
1
G
0
H
0
I
1
L
4
K
1
M
0
F
1
P
2
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 3 E: 3 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 4 M: 1 F: 0 P: 1 S: 2 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
25
C120H196N32O41S4
2871.31
8.00
+1
9.71
-0.928
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds and may inhibit nicotinic acetylcholine receptors (nAChR). {ECO:0000269|PubMed:8603741}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus nigrocinctus (Central American coral snake) (Gargantilla)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds and may inhibit nicotinic acetylcholine receptors (nAChR)..
Nicotinic acetylcholine receptor-binding protein Mnn-4 (Three-finger toxin) (3FTx)
snake
Three-finger toxin family, Short-chain subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily
Nicotinic acetylcholine receptor-binding protein Mnn-4 (Three-finger toxin) (3FTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake