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Peptide record

TPDB33291

Anticancer Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB33291
Anticancer Neurotoxin Toxicity
Cancer-related peptides Toxicity and safety peptides
AntiCP 2.0 Peptipedia dbACP iACP-DRLF NTxPred2 ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Anticancer, Neurotoxin, and Toxicity) peptide sequence curated from AntiCP 2.0, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
LKCNKLVPLFYKTCPAGKNL
Physicochemical Analysis
C104H172N26O25S2
RDEQHIMSW
LK
2250.79
9.98
4
0
8
+4
0.96
0.040
97.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1615
71.75
6
Residue Composition
number
1
A
0
R
2
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
4
L
4
K
0
M
1
F
2
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 4 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
20
C104H172N26O25S2
2250.79
9.98
+4
0.96
0.040
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This three-finger cytotoxin has antiproliferative, cytotoxic and apoptotic activities. Both in vivo and in vitro experimental results suggests that this protein possess anticancer potential. Also shows neurotoxicity, cardiotoxicity and myotoxicity. {ECO:0000269|PubMed:16511326, ECO:0000269|PubMed:17055549}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Daboia russelii (Russel's viper) (Vipera russelii)
Neurotoxin
This three-finger cytotoxin has antiproliferative, cytotoxic and apoptotic activities. Both in vivo and in vitro experimental results suggests that this protein possess anticancer potential.
Cytotoxin drCT-1 (drCT-I)
snake
Three-finger toxin family, Short-chain subfamily, Type IA cytotoxin sub-subfamily
Evidence at protein level
Apoptosis Cardiotoxin Cytolysis Direct protein sequencing Membrane Myotoxin Neurotoxin Secreted Target cell membrane Target membrane Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Apoptosis Cardiotoxin Cytolysis Direct protein sequencing Membrane Myotoxin Neurotoxin Secreted Target cell membrane Target membrane Toxin
Neurotoxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type IA cytotoxin sub-subfamily
Cytotoxin drCT-1 (drCT-I)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake