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Peptide record

TPDB33225

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB33225
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LICYNDHGYTGKTTETCENGETTCYEKSR
Physicochemical Analysis
C137H210N38O52S3
AQMFPWV
T
3317.58
4.76
4
5
5
-2
10.49
-1.183
26.90
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
4595
138.50
15
Residue Composition
number
0
A
1
R
2
N
1
D
3
C
4
E
0
Q
3
G
1
H
1
I
1
L
2
K
0
M
0
F
0
P
1
S
6
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 3 E: 4 Q: 0 G: 3 H: 1 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 6 W: 0 Y: 3 V: 0
Chemical Descriptors
29
C137H210N38O52S3
3317.58
4.76
-2
10.49
-1.183
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. {ECO:0000250|UniProtKB:F5CPD6}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus frontalis (Coral snake)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission..
Frontoxin VI (FTx VI)
snake
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Frontoxin VI (FTx VI)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake