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Peptide record

TPDB33208

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB33208
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LICFNDFSPTARTLEYCQIGITTYNPS
Physicochemical Analysis
C137H207N33O43S2
HKMWV
T
3068.47
4.07
1
2
10
-1
0.37
0.033
75.93
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
3105
101.19
13
Residue Composition
number
1
A
1
R
2
N
1
D
2
C
1
E
1
Q
1
G
0
H
3
I
2
L
0
K
0
M
2
F
2
P
2
S
4
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 2 E: 1 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 0 M: 0 F: 2 P: 2 S: 2 T: 4 W: 0 Y: 2 V: 0
Chemical Descriptors
27
C137H207N33O43S2
3068.47
4.07
-1
0.37
0.033
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus pyrrhocryptus (Coral snake)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission..
Weak neurotoxin E3
snake
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Weak neurotoxin E3
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake