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Peptide record

TPDB33204

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB33204
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LICFICFSPTAH
Physicochemical Analysis
C63H94N14O15S2
RNDEQGKMWYV
CIF
1351.64
7.00
1
0
6
-0
-2.41
1.575
105.83
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
9.25
4
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
1
H
2
I
1
L
0
K
0
M
2
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 1 K: 0 M: 0 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C63H94N14O15S2
1351.64
7.00
-0
-2.41
1.575
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probably blocks muscarinic acetylcholine receptors (CHRM), since it inhibits the binding of the selective muscarinic ligand [3H]QNB and inhibits the carbachol-induced [3H]inositol phosphate accumulation in rat hippocampus. {ECO:0000269|PubMed:22005021}.

Target

acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus lemniscatus (South American coral snake)
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Probably blocks muscarinic acetylcholine receptors (CHRM), since it inhibits the binding of the selective muscarinic ligand [3H]QNB and inhibits the carbachol-induced [3H]inositol phosphate accumulation in rat hippocampus..
Muscarinic toxin Mlalpha (MT-Mlalpha)
snake
Three-finger toxin family
Evidence at protein level
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Evidence at protein level
Three-finger toxin family
Muscarinic toxin Mlalpha (MT-Mlalpha)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake