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Peptide record

TPDB33159

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB33159
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
LFECVLSCDIKKNGKPCKPKGEKKCSGGWRCKINFCLKV
Physicochemical Analysis
C193H320N54O50S6
AQHMTY
K
4389.36
9.55
10
3
10
+7
9.32
-0.385
64.87
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5875
133.85
10
Residue Composition
number
0
A
1
R
2
N
1
D
6
C
2
E
0
Q
4
G
0
H
2
I
3
L
9
K
0
M
2
F
2
P
2
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 6 E: 2 Q: 0 G: 4 H: 0 I: 2 L: 3 K: 9 M: 0 F: 2 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
39
C193H320N54O50S6
4389.36
9.55
+7
9.32
-0.385
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that inhibits voltage-gated calcium channels in rat cerebellar granule cells (IC(50)<200 nM) (Ref.1). Is lethal to cockroaches (By similarity). {ECO:0000250|UniProtKB:P61509, ECO:0000269|Ref.1}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Aphonopelma sp. (American tarantula)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Toxin that inhibits voltage-gated calcium channels in rat cerebellar granule cells (IC(50)<200 nM) (Ref.1). Is lethal to cockroaches (By similarity)..
Omega-theraphotoxin-Asp1a (Omega-TRTX-Asp1a) (Peptide 6-6)
spider
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Omega-theraphotoxin-Asp1a (Omega-TRTX-Asp1a) (Peptide 6-6)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider