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Peptide record

TPDB33135

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB33135
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
LFECSFSCEQEKEGDKPCKKKKCKGGWKCKFNMCVKV
Physicochemical Analysis
C187H300N50O52S7
ARHITY
K
4305.16
8.86
10
5
8
+5
13.62
-0.846
26.22
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5875
136.46
10
Residue Composition
number
0
A
0
R
1
N
1
D
6
C
4
E
1
Q
3
G
0
H
0
I
1
L
10
K
1
M
3
F
1
P
2
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 6 E: 4 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 10 M: 1 F: 3 P: 1 S: 2 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
37
C187H300N50O52S7
4305.16
8.86
+5
13.62
-0.846
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Lethal neurotoxin that blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I. {ECO:0000269|PubMed:10424342}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Postsynaptic neurotoxin
Lethal neurotoxin that blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I..
U1-theraphotoxin-Hs1b (U1-TRTX-Hs1b) (Huwentoxin-2 form 2) (Huwentoxin-II) (HwTx-II)
spider
Neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily
U1-theraphotoxin-Hs1b (U1-TRTX-Hs1b) (Huwentoxin-2 form 2) (Huwentoxin-II) (HwTx-II)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider