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Peptide record

TPDB33085

Neurotoxin Toxicity standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB33085
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 41-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
LDGRNAAADFETSDLLAMTIRGGCCSYPPCIANNPLCGGKR
Physicochemical Analysis
C178H288N54O58S5
QHWV
AG
4272.87
6.16
4
4
14
-0
5.36
-0.124
69.27
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1740
40.72
12
Residue Composition
number
5
A
3
R
3
N
3
D
4
C
1
E
0
Q
5
G
0
H
2
I
4
L
1
K
1
M
1
F
3
P
2
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 3 N: 3 D: 3 C: 4 E: 1 Q: 0 G: 5 H: 0 I: 2 L: 4 K: 1 M: 1 F: 1 P: 3 S: 2 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
41
C178H288N54O58S5
4272.87
6.16
-0
5.36
-0.124
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). This toxin also inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (27% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2) (PubMed:26948522). {ECO:0000250|UniProtKB:P0CE73, ECO:0000269|PubMed:26948522}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus pulicarius (Flea-bitten cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin G-protein coupled receptor impairing toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). This toxin also inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (27% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2) (PubMed:26948522)..
Alpha-conotoxin-like Pu1.2
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond G-protein coupled receptor impairing toxin Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond G-protein coupled receptor impairing toxin Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin G-protein coupled receptor impairing toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Pu1.2
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail