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Peptide record

TPDB32997

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB32997
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KVIDVKCTSPKQCLPPCKAQFGD
Physicochemical Analysis
C109H181N29O32S3
RNEHMWY
K
2505.99
8.56
4
2
6
+2
6.46
-0.326
63.48
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
125
4.99
7
Residue Composition
number
1
A
0
R
0
N
2
D
3
C
0
E
2
Q
1
G
0
H
1
I
1
L
4
K
0
M
1
F
3
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 2 C: 3 E: 0 Q: 2 G: 1 H: 0 I: 1 L: 1 K: 4 M: 0 F: 1 P: 3 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C109H181N29O32S3
2505.99
8.56
+2
6.46
-0.326
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limbatus (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels..
Hongotoxin-4 (HgTX4) (Potassium channel toxin alpha-KTx 02)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9446567}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Hongotoxin-4 (HgTX4) (Potassium channel toxin alpha-KTx 02)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9446567}.
scorpion