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Peptide record

TPDB32842

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB32842
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KKNGYAVDSSGKVAE
Physicochemical Analysis
C66H109N19O24
RCQHILMFPTW
K
1552.70
9.58
3
2
5
+1
5.78
-0.927
52.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
95.96
4
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
1
E
0
Q
2
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
15
C66H109N19O24
1552.70
9.58
+1
5.78
-0.927
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin shows an evident analgesic effect on mice, but is devoid of mammalian toxicity.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Insect toxin BmK AngP1
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11454167}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Insect toxin BmK AngP1
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11454167}.
scorpion