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Peptide record

TPDB32810

Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB32810
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KKDGYPIQENGCKY
Physicochemical Analysis
C72H111N19O23S1
ARHLMFSTWV
K
1642.85
8.78
3
2
3
+1
5.26
-1.693
27.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
181.39
5
Residue Composition
number
0
A
0
R
1
N
1
D
1
C
1
E
1
Q
2
G
0
H
1
I
0
L
3
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 1 E: 1 Q: 1 G: 2 H: 0 I: 1 L: 0 K: 3 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
14
C72H111N19O23S1
1642.85
8.78
+1
5.26
-1.693
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Beta-toxin Cn9 (Toxin-9) (Toxin II-14.4)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Beta-toxin Cn9 (Toxin-9) (Toxin II-14.4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion