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Peptide record

TPDB32809

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB32809
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KKDGYLVNKYTGCKVNCYKLGENKFCNRE
Physicochemical Analysis
C149H236N42O44S3
AQHIMPSW
K
3415.95
9.37
7
3
8
+4
8.22
-1.100
46.90
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
4595
134.52
11
Residue Composition
number
0
A
1
R
4
N
1
D
3
C
2
E
0
Q
3
G
0
H
0
I
2
L
6
K
0
M
1
F
0
P
0
S
1
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 4 D: 1 C: 3 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 3 V: 2
Chemical Descriptors
29
C149H236N42O44S3
3415.95
9.37
+4
8.22
-1.100
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and shift the voltage of activation toward more negative potentials (By similarity). This toxin is active on crustaceans. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limpidus (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and shift the voltage of activation toward more negative potentials (By similarity). This toxin is active on crustaceans..
Toxin II.9
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin II.9
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion